Non sedating benadryl alternative

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In general, the serotonin antagonists have been shown to be safe, with minimal significant side effects.

Headache, diarrhea, and fatigue (the most common side effects) occur independently of dosage and route of administration.1112 Hypersensitivity reactions to these agents occur rarely but have been associated with complications ranging from urticaria to bronchospasm and anaphylaxis.

Costs for these agents in the treatment of patients with postoperative nausea range from approximately to 5 per dose.7Antiemetics frequently are used to treat nausea induced by vestibular or central nervous system causes.

Unlike other forms of nausea, which tend to be mediated by dopamine and serotonin, vestibular system–induced nausea is mediated primarily by histamine and acetylcholine .

Although dopamine antagonists are inexpensive and have diffuse efficacy, they have an extensive side effect profile that includes sedation, orthostatic hypotension, and extrapyramidal symptoms such as tardive dyskinesia.6Rare reactions to dopamine antagonists include neuroleptic malignant syndrome and blood dyscrasias.

Because droperidol (Inapsine) has been associated with QT prolongation, 12-lead electrocardiography is recommended before treatment is initiated.

In clinical trials, serotonin antagonists have caused self-limited, asymptomatic QT prolongation and QRS widening.13 Therefore, these agents should be used with caution in patients with underlying QT prolongation.Dopamine antagonists are relatively inexpensive, typically costing approximately

In clinical trials, serotonin antagonists have caused self-limited, asymptomatic QT prolongation and QRS widening.13 Therefore, these agents should be used with caution in patients with underlying QT prolongation.

Dopamine antagonists are relatively inexpensive, typically costing approximately $1 per dose.

Rectal and parenteral doses cost three to five times more than oral doses.7Selective serotonin antagonists inhibit the action of serotonin at the 5-hydroxytryptamine) receptor in the small bowel, vagus nerve, and chemoreceptor trigger zone.

Complementary and alternative therapies, such as ginger, acupressure, and vitamin BNausea and vomiting are common complications of multiple conditions, procedures, and therapies, and adversely affect quality of life in millions of patients each year.

Pregnancy-induced nausea alone has been estimated to cause 8.5 million lost working days annually.1 Postoperative nausea and vomiting have been shown to increase hospitalization costs by $415 per patient.2 In many instances, therapy for nausea and vomiting is directed at specific, well-studied mechanisms that have been shown to cause nausea.

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In clinical trials, serotonin antagonists have caused self-limited, asymptomatic QT prolongation and QRS widening.13 Therefore, these agents should be used with caution in patients with underlying QT prolongation.Dopamine antagonists are relatively inexpensive, typically costing approximately $1 per dose.Rectal and parenteral doses cost three to five times more than oral doses.7Selective serotonin antagonists inhibit the action of serotonin at the 5-hydroxytryptamine) receptor in the small bowel, vagus nerve, and chemoreceptor trigger zone.Complementary and alternative therapies, such as ginger, acupressure, and vitamin BNausea and vomiting are common complications of multiple conditions, procedures, and therapies, and adversely affect quality of life in millions of patients each year.Pregnancy-induced nausea alone has been estimated to cause 8.5 million lost working days annually.1 Postoperative nausea and vomiting have been shown to increase hospitalization costs by $415 per patient.2 In many instances, therapy for nausea and vomiting is directed at specific, well-studied mechanisms that have been shown to cause nausea.

per dose.Rectal and parenteral doses cost three to five times more than oral doses.7Selective serotonin antagonists inhibit the action of serotonin at the 5-hydroxytryptamine) receptor in the small bowel, vagus nerve, and chemoreceptor trigger zone.Complementary and alternative therapies, such as ginger, acupressure, and vitamin BNausea and vomiting are common complications of multiple conditions, procedures, and therapies, and adversely affect quality of life in millions of patients each year.Pregnancy-induced nausea alone has been estimated to cause 8.5 million lost working days annually.1 Postoperative nausea and vomiting have been shown to increase hospitalization costs by 5 per patient.2 In many instances, therapy for nausea and vomiting is directed at specific, well-studied mechanisms that have been shown to cause nausea.

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